FertilitySmart Conceive and Impryl are UK-available fertility supplements designed to support couples trying to conceive, but they take opposite design philosophies. FertilitySmart Conceive is a comprehensive, higher-dose range with separate formulas for men and women, combining vitamins, minerals, amino acids and botanicals. Impryl is a single unisex tablet with a deliberately minimal, physiological-dose formula of eight micronutrients, built around activated methyl donors (5-MTHF folate and methylcobalamin) to support one-carbon metabolism. Both provide 400 micrograms of folate per daily serving.
Why this comparison page exists
People searching for a head-to-head between FertilitySmart and Impryl usually want one of two things: a clear ingredient comparison, or help deciding between two very different approaches to preconception nutrition. This page provides the ingredient and formulation facts side by side. It does not say one product is more effective than the other. That would be misleading, because both are food supplements regulated under the same UK framework and neither has been shown in a head-to-head clinical trial to outperform the other.
A note on the two approaches: Impryl is built on the principle that a small number of micronutrients, supplied in physiological amounts and in their activated forms, can support one-carbon metabolism (the folate, methionine, betaine and transsulfuration pathways) for both partners. It is a single tablet taken by men and women alike, and it is a patented formula made by Parthenogen. FertilitySmart Conceive takes the broader route, with separate men's and women's formulas that add selenium, antioxidants, amino acids and botanicals on top of the core fertility nutrients. The tables below set out exactly what each contains.
At-a-glance: how do the products compare?
The simplest way to read the comparison is by breadth and dose strategy. FertilitySmart Conceive is the broader, higher-dose option with formulas tailored separately to men and women. Impryl is the minimal, single-tablet option, focused on activated methyl donors and taken by both partners.
| Attribute | FertilitySmart Conceive (for Men / for Women) | Impryl (unisex) |
|---|---|---|
| Daily serving | 2 vegetarian capsules (separate men's and women's products) | 1 tablet (one unisex formula for both partners) |
| Format | Vegetarian capsule, no fillers, no artificial colours, sweeteners, flavours or binders | Tablet (1300 mg), vegan, gluten-free, lactose-free, non-GMO |
| Folate form | Folic acid, 400 µg | 5-MTHF (methylfolate), 400 µg |
| Active ingredients | Around 14 per formula (vitamins, minerals, amino acids, botanicals) | 8 (folate, B12, B6, B2, B3, zinc, betaine, L-cystine) |
| Approach | Comprehensive, higher-dose; separate formulas for men and women | Minimal, physiological-dose; activated methyl donors targeting one-carbon metabolism |
| Suitable for vegetarians / vegans | Vegetarian | Vegan (also gluten-free and lactose-free) |
| Who takes it | Men and women, via two separate products | Men and women, via one shared product |
| Where to buy | FertilitySmart direct (fertility-smart.net) | Fertility Family (UK), Amazon, and the manufacturer Parthenogen |
| Pricing | See current pricing on the Men's and Women's product pages | See current pricing at the Impryl seller (Fertility Family in the UK) |
How do the formulations compare?
Because Impryl is a single unisex tablet, the table below shows it against both FertilitySmart Conceive for Men and FertilitySmart Conceive for Women. The two products share several core nutrients (zinc, folate, vitamin B6 and B12), but FertilitySmart adds selenium, vitamin C, vitamin E, coenzyme Q10, amino acids and botanicals, while Impryl adds betaine and L-cystine and otherwise keeps to a small set of micronutrients at physiological doses.
Ingredient comparison (per daily serving)
| Nutrient / ingredient | FS Conceive for Men (per 2 capsules) | FS Conceive for Women (per 2 capsules) | Impryl (per 1 tablet) |
|---|---|---|---|
| Zinc | 15 mg (150% NRV) | 15 mg (150% NRV) | 10 mg (100% NRV, as bisglycinate) |
| Selenium | 70 µg (127% NRV) | 70 µg (127% NRV) | None |
| Folate | 400 µg as folic acid (200% NRV) | 400 µg as folic acid (200% NRV) | 400 µg as 5-MTHF (200% NRV) |
| Vitamin B6 | 2 mg (143% NRV) | 6 mg (429% NRV) | 1.4 mg (100% NRV) |
| Vitamin B12 | 6 µg (240% NRV) | 12 µg (480% NRV) | 2.5 µg as methylcobalamin (100% NRV) |
| Riboflavin (B2) | None | 1 mg (71% NRV) | 1.4 mg (100% NRV) |
| Niacin (B3) | None | 14 mg (88% NRV) | 16 mg (100% NRV) |
| Betaine (trimethylglycine) | None | None | 200 mg |
| L-Cystine | None | None | 200 mg |
| Vitamin C | 120 mg (150% NRV) | None | None |
| Vitamin E | 100 mg α-TE | Included (see label) | None |
| Coenzyme Q10 (CoQ10) | None | 100 mg | None |
| L-Arginine | 300 mg | 500 mg | None |
| L-Carnitine | 250 mg | None | None |
| L-Taurine | 100 mg | None | None |
| Chasteberry (Vitex) | None | 400 mg | None |
| Green Tea Extract | 50 mg | 180 mg | None |
| Maca Root / Dong Quai / L-Acetyl | Maca 75 mg, Dong Quai 50 mg, L-Acetyl 25 mg | None | None |
| Magnesium / Iron | None | Magnesium 400 mg, Iron 9 mg | None |
| Vitamin D3 | None (women's formula only) | 500 IU (12.5 µg) | None |
| Vitamin B1, B5, Biotin | None | B1 1 mg, B5 5 mg, Biotin 30 µg | None |
NRV = Nutrient Reference Value (UK basis). FertilitySmart figures are per 2 capsules; Impryl figures are per 1 tablet (its full daily dose). Data taken from each manufacturer's published information and re-verified 27 June 2026. Always check the current product label for the most up-to-date formulation.
What about authorised health claims?
Under UK food law (which retains authorised health claims via the GB Nutrition and Health Claims Register), only certain claims may be made for specific nutrients. Both FertilitySmart Conceive and Impryl contain nutrients that qualify for the fertility-relevant authorised claims below, with one difference: Impryl does not contain selenium, so it is not eligible for the selenium claim. No food supplement, from any brand, can legally claim to treat, cure or prevent infertility or any other condition.
| Nutrient | Authorised claim (GB Register wording) | FertilitySmart | Impryl |
|---|---|---|---|
| Zinc | "Contributes to normal fertility and reproduction" / "Contributes to the maintenance of normal testosterone levels in the blood" | Eligible (15 mg) | Eligible (10 mg) |
| Selenium | "Contributes to normal spermatogenesis" | Eligible (70 µg in Men's product) | Not present (no selenium) |
| Folate / Folic Acid | "Contributes to normal amino acid synthesis"; supplemental folate intake of 400 µg/day for at least 1 month before and 3 months after conception increases maternal folate status | Eligible (400 µg as folic acid) | Eligible (400 µg as 5-MTHF) |
| Vitamin B6 | "Contributes to the regulation of hormonal activity" | Eligible (2 to 6 mg) | Eligible (1.4 mg) |
Impryl provides its folate as 5-MTHF (methylfolate) and its vitamin B12 as methylcobalamin, both activated forms the body can use directly. FertilitySmart provides folic acid, which the body converts to the active form. Both deliver 400 µg folate per daily serving and both qualify for the authorised folate claims; the authorised claims apply to folate regardless of form.
Who is each product likely to suit?
The best preconception supplement is the one you'll actually take consistently for at least three months. Breadth, dose strategy, folate form and convenience all matter. Below is a factual summary of who tends to gravitate to each.
You may prefer Impryl if:
You prefer a minimal, physiological-dose formula rather than higher doses. You want one simple tablet that both partners can take, rather than two separate products. You want folate and vitamin B12 in their activated forms (5-MTHF and methylcobalamin), which some people prefer if they carry common MTHFR or MTRR genetic variants. You like that it is a patented formula focused on one-carbon metabolism, with brand-specific published studies. You want a vegan, gluten-free and lactose-free tablet. You are looking for betaine and L-cystine specifically.
You may prefer FertilitySmart Conceive if:
You want a more comprehensive formula that adds selenium, vitamin C, vitamin E and (in the women's product) coenzyme Q10, plus amino acids and botanicals. You want a formula tailored separately to men and to women rather than one shared tablet. You want higher doses of zinc and the B-vitamins. You want botanicals such as maca, chasteberry (vitex), dong quai and green tea, and the amino acids L-arginine, L-carnitine and taurine. You prefer to order direct from a UK brand refined since 2007, with the Pregnancy Success Offer attached to multi-month bundles.
Frequently asked questions
Is FertilitySmart Conceive the same as Impryl?
No. They are different products with different philosophies. FertilitySmart Conceive is a comprehensive range with separate men's and women's formulas, made by FertilitySmart (UK) and sold direct via fertility-smart.net. Impryl is a single unisex tablet with a minimal, methylation-focused formula, made by Parthenogen and sold in the UK through Fertility Family and Amazon. Both provide 400 µg folate, FertilitySmart as folic acid and Impryl as 5-MTHF.
Is Impryl for men or for women?
Impryl is a single unisex formula taken by both partners; the same tablet is intended for men and women trying to conceive. FertilitySmart takes a different approach, with a Conceive for Men product and a Conceive for Women product, each tailored to that partner's needs (for example, the women's product adds coenzyme Q10, chasteberry, magnesium and iron).
Can I take FertilitySmart Conceive and Impryl at the same time?
No, you should not take both at the same time. Both products contain overlapping micronutrients, including zinc, folate and B-vitamins, and combining them risks exceeding safe upper intake levels. Choose one and take it consistently. If you are unsure which is appropriate for you, speak to your GP or a registered dietitian.
What is the difference in the folate?
Impryl uses 5-MTHF (methylfolate) and FertilitySmart uses folic acid. Both deliver 400 µg per daily serving. 5-MTHF is the form the body uses directly, whereas folic acid is converted to it in the body. Both qualify for the authorised folate claims, and 400 µg per day is the level recommended for those planning to conceive.
Are these supplements suitable for vegetarians and vegans?
Impryl is vegan, gluten-free and lactose-free. FertilitySmart Conceive uses vegetarian capsules. If you require strict vegan supplementation, Impryl states it is suitable for vegans; check the current FertilitySmart label or contact the brand to confirm.
Do these supplements contain allergens?
Neither product declares the major allergens on its product page. Impryl is gluten-free and lactose-free. Always check the current pack before purchase if you have allergen concerns, as formulations can change.
Does FertilitySmart offer a money-back guarantee?
FertilitySmart offers a Pregnancy Success Offer on its multi-month bundle (see fertility-smart.net for current terms). Impryl, through its UK sellers, does not currently offer a fertility-conditional refund.
How long does it take for either supplement to "work"?
Neither product is a treatment for infertility; both are food supplements that provide nutrients which support normal reproductive function. Sperm production takes roughly 70 to 90 days, and egg development around 90 days, so preconception supplements are typically taken for at least three months. Both brands recommend taking their product for around 90 days before conception. Those trying to conceive are advised to take folate 400 µg daily for at least one month before conception and up to three months after, in line with UK Department of Health guidance.
Which is better, FertilitySmart or Impryl?
There is no published head-to-head clinical trial comparing FertilitySmart Conceive directly with Impryl. Both are food supplements regulated under UK food law and neither has been approved as a medicine. The "better" product depends on which approach fits your priorities: a comprehensive, higher-dose formula tailored separately to men and women (FertilitySmart), or a minimal, physiological-dose unisex tablet built around activated methyl donors (Impryl).
Where can I read more about individual ingredients?
The FertilitySmart Knowledge Centre has detailed articles on Folic Acid, Zinc, Selenium, CoQ10, and Sperm DNA Fragmentation in fertility contexts.
Important information
Food supplements are not a substitute for a varied and balanced diet and a healthy lifestyle. Do not exceed the recommended daily intake. Keep out of reach of young children. If you are pregnant, breastfeeding, taking any medication, or under medical supervision, consult your doctor or pharmacist before use. FertilitySmart Conceive for Women contains chasteberry (vitex); discontinue use if you become pregnant, as it is not recommended during pregnancy or breastfeeding. Food supplements are not intended to diagnose, treat, cure or prevent any disease. The information on this page is for educational purposes and is not a substitute for individual medical advice from a qualified healthcare professional.
Related reading
- FertilitySmart vs Proceive: Ingredient Comparison (how FertilitySmart compares with the Proceive range)
- FertilitySmart vs Wellman Conception: Ingredient Comparison (how FertilitySmart compares with the Vitabiotics range)
- Top 10 Fertility Supplements: What the Evidence Shows (the broader landscape of preconception supplements)
- A Complete Guide to Fertility Supplements for Women & Men (the pillar article)
- Sperm DNA Fragmentation (why male fertility nutrition matters before conception)
References
- Parthenogen. IMPRYL: micronutrient support with activated methyl donors. Available at: parthenogen.eu/impryl. Accessed 27 June 2026.
- Impryl. Impryl Ingredients. Available at: imprylusa.com/ingredients. Accessed 27 June 2026.
- FertilitySmart. FertilitySmart Conceive for Men: Supplemental Facts. Available at: fertility-smart.net/fertilitysmart-fertility-pills-for-men. Accessed 27 June 2026.
- FertilitySmart. FertilitySmart Conceive for Women: Supplemental Facts. Available at: fertility-smart.net/fertilitysmart-fertility-pills-for-women. Accessed 27 June 2026.
- Department of Health and Social Care. Folic acid: updated SACN recommendations. UK Government, 2017.
- GB Nutrition and Health Claims Register. Authorised health claims under Regulation (EC) No 1924/2006 as retained in GB law. Department for Environment, Food & Rural Affairs, updated 2025.
Marina Carter
Health & Fertility Writer at FertilitySmart
Marina Carter is FertilitySmart’s lead writer on fertility, preconception health, and reproductive nutrition. She translates the clinical and nutritional evidence base into honest, practical guidance for individuals and couples trying to conceive, working closely with the product team to ensure every article reflects current peer-reviewed research and the lived emotional reality of the fertility journey. Read Full Bio →